The HELM (Hierarchical Editing Language for Macromolecules) 2.0 project published this RFP to implement a number of enhancements to the current HELM definition and open source codebase in order to:
1. Enable the support of structural ambiguity (e.g. bioconjugates with ambiguous or unknown attachment point between drug and antibody).
2. Re-architect the toolkit source code into a more modular, API-based structure that will facilitate more service-based applications and the removal of third party dependencies.