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Maestro Pro Purchase


Maryland, United States
Government : Federal
RFI
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Federal Business Opportunities (FBO)
SOURCES SOUGHT NOTICE


1. Solicitation Number: NIHDA201800463


2. Title: Maestro Pro Purchase


3. Classification Code: 66 - Instruments and Laboratory Equipment


4. NAICS Code: 334516 - Analytical Laboratory Instrument Manufacturing


5. Description:
This is a Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding the availability and capability of all qualified sources to perform a potential requirement.


This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for research and information purposes only.


Background: The Stem Cell Translation Laboratory (SCTL) within the National Center for Advancing Translational Sciences (NCATS) Division of Preclinical Innovation (DPI) requires the Maestro Pro to meet SCTL project milestones. The Maestro Pro allows for simultaneous live, label-free recording of electrically active cells. This system will be utilized to characterize neurons; such as nociceptors and cardiomyocytes derived from induced pluripotent stem cells. Characterization of these cells with the Maestro Pro will allow SCTL scientists to gain a better understanding of the behavior of diseased cells, screen for drugs to treat that disease/disorder and examine potential toxic effects of drug candidates.

Purpose and Objectives: The purpose of this acquisition is to obtain one (1) Maestro Pro on a brand name only requirement for the Stem Cell Translation Laboratory (SCTL) within the National Center for Advancing Translational Sciences (NCATS) Division of Preclinical Innovation (DPI). This system allows SCTL scientists to measure electrical network behavior in live cells, such as nociceptors and cardiomyocytes derived from induced pluripotent stem cells, at high throughput.


The Maestro Pro is compatible with the Axion Classic and CytoView Micro Electrode Array plates which the SCTL currently utilizes in experiments, and it is imperative for the continuation of cell characterization. This system is also compatible with the NCATS' previously purchased Axion Maestro system, but allows for long term, live cell, and label-free recordings due to its fully enclosed cell growth chamber that allows for better CO2 and temperature control. The Maestro Pro is an upgraded system compared to the previous acquisition and will also allow NCATS to run two recording in parallel as more lab members are using the system currently in the lab.


Therefore, this equipment is essential for achieving the SCTL research goals of: 1) establishing detailed quality control (QC) standards to define pluripotency and differentiated cell types; 2) using multi-omics methods to assess molecular and cellular variations/signatures in cellular phenotypes derived from iPSCs; 3) develop standardized methods for producing mature cells from iPSCs that meet QC and reproducibility standards; and 4) discovering, validating and disseminating small molecule reagents to replace expensive recombinant proteins, xenogenic material and undefined media components in cell differentiation protocols


Project requirements:
1. Maestro Pro (Product # MAESTRO768PRO, Axion Biosystems)
2. Installation and Training, 2 days (Product # INT-OS, Axion Biosystems)
3. Performance Assurance Service Plan with Preventive Maintenance - Maestro Pro (Product # PASPM768PRO, Quantity: 2, Axion Biosystems)

Salient Characteristics:
The Maestro Pro system must include the following essential characteristics:
1. The system's ability to quickly and easily measure electrical network behavior in live cells at high throughput.
2. The system must be able to detect key parameters of cardiomyocyte activity, including depolarization, propagation of excitability, repolarization, beat timing, and irregular beating (arrhythmia).
3. In addition, the system must include local extracellular action potential assay which allows for recordings of extracellular action potential waveforms which are stable for 10-20 minutes or more.
4. The system must allow for quantification of action potential morphology and characterization of complex repolarization irregularities.
5. The system must fit in the allotted space within the SCTL laboratory. The dimensions must be H 22.5 CM (8.86") x W 28.0 CM (11.0") x D 45.2 CM (17.8").


The Maestro Pro system must include the following:
• 768-channel MEA system with x12 BioCore v4 chip technology
• Touchscreen real-time interface, stimulation, recording and data acquisition system
• Automated temperature and CO2 control
• Plate usage is logged via an integrated plate barcode scanner for experiment tracking
• Desktop computer, monitor, and AxIS Navigator software for acquisition and analysis
• Compatible Axion BioSystem's 12, 24, 48, and 96-well, MEA plates (SLAS compliant)
• 1 TB storage space
• Electrical stimulation of 768 microelectrodes in all wells simultaneously
• 100-240 VAC power requirements
• 100% CO2 @ 15 PSI gas requirements
• 1-year warranty
• 2 additional years option warranty with Preventive Maintenance
• On-site 2-day installation and training covering hardware, software and applications


Quantity:
One (1) x Maestro Pro system
One (1) x Installation and Training, 2 days
Two (2) x Performance Assurance Service Plan with Preventive Maintenance - Maestro Pro


Anticipated period of performance: Delivery to be made four (4) weeks ARO.


Other important considerations: Two (2) years Performance Assurance Service Plan with Preventive Maintenance - Maestro Pro, additional 1 year in-factory service and preventive maintenance plan including all parts and labor. Includes one in-factory preventive maintenance service.


Capability statement /information sought. Responses shall include a capabilities statement and the following information:


• respondents' opinions about the difficulty and/or feasibility of the potential requirement or proposed acquisition, possible solutions and approaches that may currently exist in the marketplace, and information regarding innovative ideas or concepts;


• information regarding respondents': (a) staff expertise, including their availability, experience, and formal and other training; (b) current in-house capability and capacity to perform the work; (c) prior completed projects of similar nature; (d) corporate experience and management capability; and (e) examples of prior completed Government contracts, references, and other related information;


• general information regarding the respondent's estimate or rough order of magnitude of the effort or time that may be required for completion of the work. (NOTE: This type of information may only be requested as part of an RFI. However, care must be exercised in requesting such information. Information requested must be: (a) necessary; (b) broad in scope; and (c) used for planning purposes only. Detailed estimates must not be requested.);


The respondent must also provide their DUNS number, organization name, address, point of contact, and size and type of business (e.g., 8(a), HubZone, etc., pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements.


One (1) copy of the response is required and must be in Microsoft Word or Adobe PDF format using 11-point or 12-point font, 8-1/2" x 11" paper size, with 1" top, bottom, left and right margins, and with single or double spacing.


The information submitted must be must be in and outline format that addresses each of the elements of the project requirement and in the capability statement /information sought paragraphs stated herein. A cover page and an executive summary may be included but is not required.


The response is limited to ten (10) page limit. The 10-page limit does not include the cover page, executive summary, or references, if requested.


The response must include the respondents' technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses.


All responses to this notice must be submitted electronically to the Contract Specialist and Contracting Officer. Facsimile responses are NOT accepted.


The response must be submitted to Jessica Adams, Contract Specialist, at e-mail address jessica.adams@nih.gov.


The response must be received on or before August 22, 2018, 1:00pm, Eastern Time.


Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work.


Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation.


Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s)."


 


Jessica Adams, Contract Specialist, Email jessica.adams@nih.gov - Jeffrey Schmidt, Contracting Officer, Email jeffrey.schmidt@nih.gov

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