MULTI-SHOT HIGH-PRESSURE CELL DISRUPTOR
This Small Business Sources Sought Notice is for information and planning purposes only and shall not be construed as a solicitation or as an obligation or commitment by the Government. This notice is intended strictly for Market Research. The National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases is conducting a market survey to determine the availability and technical capability of qualified small business, veteran-owned small business, service-disabled veteran-owned small business or HUBZone small businesses capable of providing a Multi-Shot high-pressure cell disruptor.
NIDDK, has initiated biochemical studies of the major proteins involved in intracellular iron delivery. This requires large-scale protein purification, for which a FPLC chromatography system. The initial steps of protein purification require overexpression in bacterial systems and then lysis of bacterial cells prior to protein purification. NIDDK has been transporting samples of bacterial cells from one building to another to use equipment to disrupt cells for protein isolation. Transporting cells between buildings leads to delays and degradation of protein quality. Protein is oxygen sensitive, we need to be able to quickly isolate the protein and move it to an oxygen-free environment. These steps would be greatly facilitated by having access to a cell disruption system in our laboratory. Because our protein is oxygen sensitive, we need to be able to perform disruption quickly, in our laboratory, where we can minimize exposure to oxygen.
The MultiShot disruptor will process the volume of sample we require in minimal time, without the need for pre-disruption processing.
Incorporates our unique disruption head, precise hydraulic operating and control system with an automatically supplied, continuous flow Cell Disruptor.
Disruption pressure easily and accurately set and displayed digitally with a range of 1KPSI through to 40KPSI as standard
Touch screen control of disruption cycle, automatic shut down when process complete
Cell Disrupter controls peristalic process pump for automatic supply of sample.
Disruption head mounted in stainless steel tray to avoid spillage
Partial containment and simple externally controlled CIP
Internal relief valve fitted for reverse flow of cleaning fluids
Place of Performance: National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892.
The intended procurement will be classified under North American Industrial Classification (NAICS) code 334516 with a size standard of 500. Offerors who are capable of providing at a minimum, fifty-one percent (51%) of the required/actual services of this solicitation. All respondents are requested to identify their firm's size and type of business. Interested firms responding to this market survey must provide (a) capability statement demonstrating their experience, skills and capability to fulfill the Government's requirements for the above. The capability statement shall be in sufficient enough detail, but not to exceed 15 pages, so that the Government can determine the experience and capability of your firm to provide the requirements above. Your capability statement, not to exceed 15 pages, should include references. Capability statement must be received at the address identified in this synopsis by no later than 10 days by 11:00 A.M. local time at designated location on July 24, 2014.
Responses by FAX or E-MAIL WILL NOT BE ACCEPTED. This synopsis is for information and planning purposes and is not to be construed as a commitment by the Government, nor will the Government pay for information solicited.
Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provided feedback to respondents with respect to any information submitted. After a review of the responses received, a pre-solicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate response to a solicitation. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s)."
Any questions regarding this announcement must be sent via email to [email protected] and must include solicitation NIHLM2014214 in the subject line of email.
PLEASE NOTE: In order to receive an award, contractor must be registered and have valid certification in the System for Award Management (SAM) [formerly CCR].
V. Lynn Griffin, Fax 301-480-8501, Email [email protected]
